A Pilot Study of the Safety and Immunogenicity of the Rotavirus Vaccine in Infants with Intestinal Failure – Assessment of Hepatic Function in Short Bowel Syndrome Using the Novel 13C-Methionine Breath Test – Neurodevelopmental Outcomes of Children with Intestinal Failure – Pediatric Intestinal Failure Consortium
Patrick J. Javid, MD Assistant Professor Pediatric intestinal failure, of which short bowel syndrome is the most common etiology, has been transformed into a chronic disease. Many infants with intestinal failure are surviving to school age and beyond. The evolution of pediatric intestinal failure is directly attributable to advances in medical, nutritional, and surgical treatments of this disease. As such, there are now multiple opportunities for clinically relevant and effective research into different aspects of pediatric intestinal failure.
John Waldhausen, MD Professor Pediatric surgery is in general a very clinically oriented field, although there is an increasing emphasis on research in our division. Most of our division’s research activity in the past has been oriented toward outcomes and what we do in the operating room and on the hospital ward. It is important to examine the way we practice surgery, and by either randomized prospective trial or by retrospective review, determine how we can make changes that will benefit our patients. These studies may involve a wide spectrum of both congenital defects and problems encountered in the older child. While retrospective clinical reviews may be useful, much of our current outcomes research is now driven by examination of large patient databases that cover large populations. We are using these databases in a rigorous academic manner to critically evaluate how various treatments affect an entire population rather than just the smaller number that we may have cared for. We are also looking at quality of life studies to better evaluate how what we do affects our patients in the long run. Studies of this sort have been sorely lacking in our field.