Christopher Little, MD

Dr. Christopher Little



Appleton, WI

Personal Interests:

Cribbage and Thunderbird hockey

Resident Bio:

I am in the research track of the general surgery program. I was raised in a Navy family, originally from Jacksonville, FL. We moved around the southeast coast before settling in Appleton, WI. I went to both undergrad and medical school at the University of Wisconsin in Madison, before moving to Seattle for residency.

Undergraduate School:

University of Wisconsin-Madison

Medical School:

University of Wisconsin-Madison

General Surgery or Preliminary Program:

General Surgery – 7 year track

Clinical Interests:

Transplant surgery

Professional Activities:

Research and education


  1. Zhang M, Urabe G, Little C, et al. HDAC6 Regulates the MRTF-A/SRF Axis and Vascular Smooth Muscle Cell Plasticity. JACC Basic Transl Sci. 2018;3(6):782-795.
  2. Grodstein EI, Little C, Molmenti EP, Mezrich JD. Renal Transplantation as a Platform for Teaching Residents Open Vascular Surgical Techniques: Effects on Early Graft Function. J Surg Educ. 2018
  3. Zhu Y, Takayama T, Wang B, Kent A, Zhang M, Binder BY, Urabe G, Shi Y, DiRenzo D, Zhou Y, Little C, Roenneburg DA, Shi XD, Li L, Murphy WL, Kent KC, Ke J, Guo LW. “Restenosis Inhibition and Re-differentiation of TGFβ/Smad3-activated Smooth Muscle Cells by Resveratrol.” Sci Rep. 2017;7:41916.
  4. Guo LW, Wang B, Goel SA, Little C, Takayama T, Shi XD Ronneburg D, DiRenzo D, Kent KC. “Halofuginone stimulates adaptive remodeling and preserves re-endothelialization in balloon-injured rat carotid arteries.” Circ Cardiovasc Interv. 2014;7(4):594-601.
  5. Zhang J*, Little CJ*, Tremmel DM, Yin JC, Wesley CS. “Notch-inducible hyperphosphorylated CREB and its ultradian oscillation in long-term memory formation.” J Neurosci. 2013;33(31):12825-34. (* co-first authors)
  6. Tremmel DM, Resad S, Little CJ, Wesley CS. Notch and PKC are involved in formation of the lateral region of the dorso-ventral axis in Drosophila embryos. PLoS ONE. 2013;8(7):e67789.